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ALLIANCE PHARMACEUTICALS LIMITED - CHANGE IN BOARD OF DIRECTORS                 
ALLIANCE PHARMACEUTICALS LIMITED                                                
(Incorporated in the Republic of South Africa)                                  
(Registration number 1981/006145/06)                                            
Share code ALN    ISIN:  ZAE000011110                                           
Share code ACN    ISIN:  ZAE000011847                                           
(`Alliance`)                                                                    
CHANGE TO BOARD OF DIRECTORS                                                    
Shareholders are advised in terms of 3.59 of the Listings Requirements of the   
JSE Securities Exchange South Africa that W H Pieters has been appointed as a   
non executive director of Alliance with immediate effect and J E Forman has been
appointed as an executive director of Alliance with immediate effect.           
26 August 2004                                                                  
Johannesburg                                                                    
SPONSOR                                                                         
SASFIN CORPORATE FINANCE                                                        
A DIVISION OF SASFIN BANK LIMITED

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